Prostaglandin antagonist
A Prostaglandin antagonist is a hormone antagonist acting upon prostaglandin.
NSAIDs inhibit cyclooxygenase and reduce prostaglandin synthesis. Corticosteroids inhibit phospholipase A2 production by boosting production of lipocortin, an inhibitor protein. Relatively new drugs, known as COX-2 selective inhibitors or coxibs, are used as specific inhibitors of COX-2. The development of these drugs allowed the circumvention of the negative gastrointestinal effects while effectively reducing inflammation.

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Prostaglandin antagonist - Wikipedia, the free encyclopedia
A Prostaglandin antagonist is a hormone antagonist acting upon prostaglandin. NSAIDs inhibit cyclooxygenase and reduce prostaglandin synthesis.
en.wikipedia.org/wiki/Prostaglandin_antagonist
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Prostaglandin - Wikipedia, the free encyclopedia
Prostaglandins are a group of lipid compounds that are derived enzymatically from .... See also: Prostaglandin antagonist and Mechanism of action of aspirin.
en.wikipedia.org/wiki/Prostaglandin
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Studies on prostaglandin antagonists
Three Prostaglandin antagonists have been examined for their ability to block PGE2 and PGF2α on human, guinea-pig and isolated rat gastrointestinal muscle.
www.ncbi.nlm.nih.gov/pmc/articles/PMC1665751/
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Adenosine as a natural prostaglandin antagonist in vascular smooth ...
Prostaglandins. 1977 Jul;14(1):109-17. Adenosine as a natural Prostaglandin antagonist in vascular smooth muscle. Ally AI, Horrobin DF, Karmali RA, Morgan ...
www.ncbi.nlm.nih.gov/pubmed/897205
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Prostaglandin Antagonists (definition) - Reference.MD
Prostaglandin antagonists - definition. ... See Also Cyclooxygenase Inhibitors, Other names Prostaglandin Inhibitors; Inhibitor, Prostaglandin; Antagonist, ...
www.reference.md/files/D011/mD011448.html
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Respiratory Research | Full text | Antagonism of the prostaglandin ...
Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor ...
respiratory-research.com/content/8/1/16
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Figures and Tables : Antagonism of the prostaglandin D: 2 ... - Nature
Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 ...
www.nature.com/nrd/journal/v6/n4/fig_tab/nrd2266_ft.html
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Hair Loss Help Forums - Prostaglandin D2 RECEPTOR 2 ANTAGONIST ...
Ok with the recent news of this protein found more so in the bald areas of a scalp, I was doing a bit of looking around and found this post by ...
www.hairlosshelp.com/forums/messageview.cfm?catid=10&threadid=99451
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prostaglandin antagonist (CHEBI:49023)
ChEBI Name, Prostaglandin antagonist. ChEBI ID, CHEBI:49023. Definition, A compound that inhibits the action of prostaglandins. Stars, This entity has been ...
www.ebi.ac.uk/chebi/chebiOntology.do?chebiId=CHEBI:49023
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Adenosine as a natural prostaglandin antagonist in ... - ScienceDirect
Adenosine has actions on smooth muscle similar to those of prostaglandin (PG) antagonists. Like some PG antagonists it is a phosphodiesterase inhibitor and ...
www.sciencedirect.com/science/article/pii/0090698077901599
Search results for "Prostaglandin antagonist"
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Prostaglandin antagonist in science
Prostaglandin EP2 Receptor Antagonists for Reducing Inflammation ...
Prostaglandin EP2 Receptor Antagonists for Reducing Inflammation. Emory University posted on 02/16/2012. Request more info via email request more info ...
[PDF]Small molecule antagonist reveals seizure ... - Emory University
Edited by Solomon H. Snyder, Johns Hopkins University School of Medicine, Baltimore, MD, .... compounds as antagonists of human prostaglandin EP2 receptor.
Respiratory Research | Full text | Antagonism of the prostaglandin ...
Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse ... 1 Dept. Experimental Medical Science, Lund University, Sweden.
Small molecule antagonist reveals seizure-induced mediation of ...
Feb 21, 2012 ... Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Jianxiong Jianga,1 ...
Antagonism of the prostaglandin D2 receptor ... - Lund University
Title, Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Author/s, Lena Uller, Jesper ...
Delay of preterm birth in sheep by THG113.31, a prostaglandin ...
Department of Physiology, Monash University, Clayton, Victoria, Australia. OBJECTIVE: A novel prostaglandin F2alpha receptor antagonist, THG113.31, was ...
PLOS ONE: Peroxisome Proliferator-Activated Receptor-γ Agonist ...
Peroxisome Proliferator-Activated Receptor-γ Agonist 15d-Prostaglandin J2 ... 10th People's Hospital, Tongji University School of Medicine, Shanghai, China. X .
The Effects of a Prostaglandin Inhibitor on Ovulation and the ...
The Effects of a Prostaglandin Inhibitor on Ovulation and the Menstrual Cycle. This study has been completed. Sponsor: Oregon Health and Science University.
Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and ...
Agonist and Antagonist Effects of 15R-Prostaglandin (PG) D2 and ... Meakins- Christie Laboratories, Department of Medicine, McGill University, Montreal, ...
[PDF]Prostaglandin Antagonists - Springer
Prostaglandin antagonists used as an approach to the synthesis of prostaglandin antagon- ists by a group of investigators at the University of Chicago. (Fried ...
Books on the term Prostaglandin antagonist
The Eicosanoids
The Eicosanoids
Peter Curtis-Prior, 2004
Br J Pharmacol, 104, 596–602. Fried J et al (1969) Prostaglandin antagonists: synthesis and smooth muscle activity. Nature, 223, 208–210. Fujimura M, Sakamoto S, Kamio Y and Matsuda T (1993) Effect of a leukotriene antagonist, ONO-1078 ...
Recent Advances in Prostaglandin, Thromboxane, and Leukotriene ...
Recent Advances in Prostaglandin, Thromboxane, and Leukotriene ...
Helmut Sinzinger, 1997
Aggregation was induced with the stable thromboxane analog U 46619 (9,1 l- dideoxy-9(X -epoxymethano-prostaglandin F2a); in canine PRP, aggregation was initiated with the OC2- adrenoceptor agonist adrenaline (10 uM) followed after 30 ...
ADV IN PHARMACOLOGY &CHEMOTHERAPY
ADV IN PHARMACOLOGY &CHEMOTHERAPY
Silvio Garattini, Robert Robert Julius Schnitzer, 1981
Consistent also is the observation that sodium salicylate, which is a much weaker inhibitor of prostaglandin synthetase ... Clark and Cumby (1975b) found that the Prostaglandin antagonist SC 19220 antagonized pyrogen fever in cats only at ...
Advances in Prostaglandins E Research and Application: 2012 ...
Advances in Prostaglandins E Research and Application: 2012 ...
2012
New research, 'Terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, prevents hypertensive vascular hypertrophy and fibrosis,' is the subject of a report. According to recent research from Milan, Italy, “Thromboxane A(2) ...
Obstructive Airway Diseases: Role of Lipid Mediators
Obstructive Airway Diseases: Role of Lipid Mediators
Dr. Abhijit Ray, Punit Kumar Srivastave, 2011
Identification of an indole series of prostaglandin D2 receptor antagonists. ... Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4 (4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocy clopenta[b] indol- ...
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Blog posts on the term
Prostaglandin antagonist
Respiratory Research | Full text | Antagonism of the prostaglandin D2receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation
Mast cell-derived prostaglandin D2 (PGD2), may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous molecule expressed on TH2 cells (CRTH2), a high affinity receptor for prostaglandin D2, mediates trafficking of TH2-cells, mast cells, and eosinophils to inflammatory sites, and has recently attracted interest as target for treatment of allergic airway diseases. The present study involving mice explores the specificity of CRTH2 antagonism of TM30089, which is structurally closely related to the dual TP/CRTH2 antagonist ramatroban, and compares the ability of ramatroban and TM30089 to inhibit asthma-like pathology.
respiratory-research.com/content/8/1/16
Prostaglandin F2α Supplier | CAS 38562-01-5 | Tocris Bioscience
View and buy high purity Prostaglandin F2α from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents
www.tocris.com/dispprod.php?ItemId=290443
Terutroban, a thromboxane/prostaglandin endoperoxide receptor antagonist, prevents hypertensive vascular hypertrophy and fibrosis
ajpheart.physiology.org/content/300/3/H762.abstract
wgasdg: A prostaglandin E (PGE) receptor EP4 antagonist protects natural killer cells from PGE2-mediated immunosuppression and inhibits breast cancer metastasis.
dsfaaaa.blogspot.com/2013/03/a-prostaglandin-e-pge-receptor-ep4.html
PLOS ONE: Peroxisome Proliferator-Activated Receptor-γ Agonist 15d-Prostaglandin J2 Mediates Neuronal Autophagy after Cerebral Ischemia-Reperfusion Injury
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
www.plosone.org/article/info:doi/10.1371/journal.pone.0055080
Allergy Notes: CRTH2 receptor antagonist that blocks prostaglandin D2 is under development as new asthma therapy
CRTH2 is a G-protein-coupled Chemoattractant Receptor-homologous molecule on Th2 cells (CRTH2). CRTH2 binds PGD2 http://bit.
allergynotes.blogspot.com/2009/09/crth2-receptor-antagonist-that-blocks.html
Interaction Of Adrenergic Antagonists With Prostaglandin E2 And Tetrahydrocannabinol
Interaction of adrenergic antagonists with prostaglandin E2 and tetrahydrocannabinol in the eye Keith Green and Keun Kim Both a- and /3-adrenergic antagonists have been utilized in an attempt to
www.420magazine.com/forums/glaucoma/155215-interaction-adrenergic-antagonists-prostaglandin-e2-tetrahydrocannabinol.html
Scalable Synthesis of a Prostaglandin EP4 Receptor Antagonist - The Journal of Organic Chemistry (ACS Publications)
pubs.acs.org/doi/abs/10.1021/jo1004197
Arthritis Research & Therapy | Full text | Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability
Osteoarthritis (OA) is a common cause of disability in older adults. We have previously reported that an agonist for subtypes EP2 of the prostaglandin E2 receptor (an EP2 agonist) promotes the regeneration of chondral and osteochondral defects. The purpose of the current study is to analyze the effect of this agonist on articular cartilage in a model of traumatic degeneration.
arthritis-research.com/content/13/5/r146
Effects on prostaglandin E 2 and castor oil induced diarrhea in m | Inhibitor|Kinase Inhibitors
Posted on March 27, 2013 by ainh8116.
a-inhibitor.com/effects-on-prostaglandin-e-2-and-castor-oil-induced-diarrhea-in-m
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