Oligouridylation
Polyuridylation, also called oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. One group of RNAs that can be polyuridylated are histone mRNAs that lack a poly(A) tail. Polyuridylation of a histone mRNA promotes its degradation, involving the exosome. Other RNAs in Arabidopsis and mouse have been seen to be polyuridinylated after cleavage.

This is an excerpt from the article Oligouridylation from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article Oligouridylation at en.wikipedia.org was accessed 9 times in the last 30 days. (as of: 07/26/2013)
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Polyuridylation - Wikipedia, the free encyclopedia
Polyuridylation, also called Oligouridylation, is the addition of several uridine nucleotides to the 3' end of an RNA. One group of RNAs that can be polyuridylated ...
en.wikipedia.org/wiki/Polyuridylation
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Widespread RNA 3'-end oligouridylation in mammals.
RNA. 2012 Mar;18(3):394-401. doi: 10.1261/rna.029306.111. Epub 2012 Jan 30. Widespread RNA 3'-end Oligouridylation in mammals. Choi YS, Patena W, ...
www.ncbi.nlm.nih.gov/pubmed/22291204
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(3 ) end—oligouridylation as a step on the path to destruction
PERSPECTIVE. New ways to meet your (3 ) end—Oligouridylation as a step on the path to destruction. Carol J. Wilusz2 and Jeffrey Wilusz1. Department of ...
genesdev.cshlp.org/content/22/1/1.full.pdf
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-end oligouridylation in mammals ′ Widespread RNA 3
Access the most recent version at doi: 2012 18: 394-401 originally published online January 30, 2012. RNA. Yun S. Choi, Weronika Patena, Andrew D. Leavitt, ...
mcmanuslab.ucsf.edu/sites/mcmanuslab.ucsf.edu/files/pubs/Choi-RNA-2012.pdf
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Degradation of histone mRNA requires oligouridylation followed by ...
Degradation of histone mRNA requires Oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Mullen TE ...
f1000.com/prime/1100262
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Eri1 degrades oligouridylated histone mRNAs. : Eri1 degrades the ...
Dec 2, 2012 ... The exoribonuclease Eri1 binds the stem-loop of histone mRNAs, but the functional significance of this interaction has been unclear.
www.nature.com/nsmb/journal/v20/n1/fig_tab/nsmb.2450_F3.html
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Oligouridylation of histone mRNA represses translation and ...
Dec 2, 2012 ... The exoribonuclease Eri1 binds the stem-loop of histone mRNAs, but the functional significance of this interaction has been unclear.
www.nature.com/nsmb/journal/v20/n1/fig_tab/nsmb.2450_F5.html
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ProQuest Document View - On RNA 3'-end Oligouridylation - Umi.com
Non-templated 3'-end Oligouridylation is a poorly characterized RNA modification found in many species including humans. Recent studies have reported ...
gradworks.umi.com/34/93/3493668.html
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Degradation of histone mRNA requires oligouridylation ... - UniProt
Mullen T.E., Marzluff W.F.. Histone mRNAs are rapidly degraded at the end of S phase or when DNA replication is inhibited. Histone mRNAs end in a conserved ...
www.uniprot.org/citations/18172165
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XRN1 Gene - GeneCards | XRN1 Protein |…
Complete information for XRN1 gene (protein-coding), 5'-3' exoribonuclease 1
www.genecards.org/cgi-bin/carddisp.pl?gene=XRN1
Search results for "Oligouridylation"
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Oligouridylation in science
Widespread RNA 3'-end oligouridylation in mammals.
Jan 30, 2012 ... Biomedical Sciences Graduate Program, University of California, San Francisco ... Nontemplated 3'-end Oligouridylation of RNA occurs in many ...
[PDF](3 ) end—oligouridylation as a step on the path to destruction
... Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA. Messenger ... newly discovered 3 modification—Oligouridylation—.
ProQuest Document View - On RNA 3'-end Oligouridylation - Umi.com
Learn more... ProQuest. On RNA 3'-end Oligouridylation. by Choi, Yun S., Ph.D., UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, 2011, 108 pages; 3493668 ...
[PDF]Widespread RNA 3 - McManus Lab - University of California, San ...
Jan 30, 2012 ... Widespread RNA 39-end Oligouridylation in mammals ... 1Biomedical Sciences Graduate Program, University of California, San Francisco, San ...
Widespread RNA 3'-end oligouridylation in mammals. - BioInfoBank ...
Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California 94143, USA. Nontemplated 3'-end Oligouridylation of ...
Oligouridylation of histone mRNA represses translation and ...
Dec 2, 2012 ... New studies now indicate that 3A Oligouridylation of histone mRNAs enables the Lsm1–7 complex to bind the oligo(U) tail and to interact with ...
Degradation of histone mRNA requires oligouridylation followed by
Degradation of histone mRNA requires Oligouridylation followed by decapping and ... Department of Biochemistry and Biophysics, University of North Carolina at ...
[PDF]View - University of North Carolina at Chapel Hill
Oligouridylation FOLLOWED BY BIDIRECTIONAL DECAY. Thomas Edward Mullen, Jr. A dissertation submitted to the faculty of the University of North ...
Books on the term Oligouridylation
The Role of Protein Degradation in Maintaining Genome Stability ...
The Role of Protein Degradation in Maintaining Genome Stability ...
Jonathan Russell Hall, 2008
This dissertation researches how Cdc6 and Cdt1 are regulated in response to DNA damage, and the consequences when these regulatory pathways are inhibited.
Characterizing the Pregnane X Receptor's Interactions and ...
Characterizing the Pregnane X Receptor's Interactions and ...
Virginia Elaine Carnahan, 2007
Pregnane X Receptor is a ligand-activated transcription factor critical in protecting tissues from xenobiotics and endobiotics.
The Unique Role of Polymerase Mu in Nonhomologous End Joining
The Unique Role of Polymerase Mu in Nonhomologous End Joining
Bryan Joseph Davis, Bryan Joseph Davis, 2008
However, unlike TdT, I show pol mu is not promiscuously template independent. I argue this is in part because pol mu also possesses an element of the more canonical template dependent pol X family members.
Molecular Biology of RNA Processing and Decay in Prokaryotes
Molecular Biology of RNA Processing and Decay in Prokaryotes
2009
Histone mRNAs, which do not carry stabilizing poly(A) tails, are oligouridylated, decapped, and degraded simultaneously from the 5′‐end and from the 3′‐end (64). The mechanisms described above are responsible for general mRNA ...
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Blog posts on the term
Oligouridylation
Widespread RNA 3′-end oligouridylation in mammals
A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
rnajournal.cshlp.org/content/early/2012/01/30/rna.029306.111
"Post-transcriptional Regulation of Mammalian Gene Expression in Non-co" by Jing Lin
Tumor Suppressor Candidate 2 (TUSC2) is a novel tumor suppressor gene located in the human chromosome 3p21.3 region. TUSC2 mRNA transcripts could be detected on Northern blots in both normal lung and some lung cancer cell lines, but no endogenous TUSC2 protein could be detected in a majority of lung cancer cell lines. Mechanisms regulating TUSC2 protein expression and its inactivation in primary lung cancer cells are largely unknown. We investigated the role of the 5’- and 3’-untranslated regions (UTRs) of the TUSC2 gene in the regulation of TUSC2 protein expression. We found that two small upstream open-reading frames (uORFs) in the 5’UTR of TUSC2 could markedly inhibit the translational initiation of TUSC2 protein by interfering with the “scanning” of the ribosome initiation complexes. Site-specific stem-loop array reverse transcription-polymerase chain reaction (SLA-RT-PCR) verified several micoRNAs (miRNAs) targeted at 3’UTR and directed TUSC2 cleavage and degradation. In addition, we used the established let-7-targeted high mobility group A2 (Hmga2) mRNA as a model system to study the mechanism of regulation of target mRNA by miRNAs in mammalian cells under physiological conditions. There have been no evidence of direct link between mRNA downregulation and mRNA cleavages mediated by miRNAs. Here we showed that the endonucleolytic cleavages on mRNAs were initiated by mammalian miRNA in seed pairing style. Let-7 directed cleavage activities among the eight predicted potential target sites have varied efficiency, which are influenced by the positional and the structural contexts in the UTR. The 5’ cleaved RNA fragments were mostly oligouridylated at their 3’-termini and accumulated for delayed 5’–3’ degradation. RNA fragment Oligouridylation played important roles in marking RNA fragments for delayed bulk degradation and in converting RNA degradation mode from 3’–5’ to 5’–3’ with cooperative efforts from both endonucleolytic and non-catalytic miRNA-induced silencing complex (miRISC). Our findings point to a mammalian miRNA-mediated mechanism for the regulation of mRNA that miRNA can decrease target mRNA through target mRNA cleavage and uridine addition
digitalcommons.library.tmc.edu/utgsbs_dissertations/299/
Journal ToCs / A role for the Perlman syndrome exonuclease Dis3l2 in the Lin28–let-7 pathway
The pluripotency factor Lin28 blocks the expression of let-7 microRNAs in undifferentiated cells during development, and functions as an oncogene in a subset of cancers. Lin28 binds to let-7 precursor (pre-let-7) RNAs and recruits 3′ terminal uridylyl transferases to selectively inhibit let-7 biogenesis.
journaltocs.info/blog/2013/04/17/a-role-for-the-perlman-syndrome-exonuclease-dis3l2-in-the-lin28-let-7-pathway-2/
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