Oleocanthal
Oleocanthal is a phenylethanoid, a type of natural phenolic compound found in extra-virgin olive oil. It appears to be responsible for the burning sensation that occurs in the back of the throat when consuming extra-virgin olive oil. Oleocanthal is a tyrosol ester and its chemical structure is related to oleuropein that is also found in olive oil.
Oleocanthal has been found to be have anti-inflammatory and antioxidant properties in vitro. Similar to classical NSAIDs, it is a non-selective inhibitor of cyclooxygenase (COX). 50g (more than three and a half tablespoons) of a typical extra virgin olive oil per day contains an amount of oleocanthal with similar in vitro anti-inflammatory effect as 1/10 of the adult ibuprofen dose. It is therefore suggested that long-term consumption of small quantities of oleocanthal from olive oil may be responsible in part for the low incidence of heart disease and Alzheimer's disease associated with a Mediterranean diet. However, 50 g is a great deal of olive oil for most consumers; moreover, the absorption, metabolism, and distribution of oleocanthal is not yet well-characterized, and it is not known whether these in vitro effects actually occur in the body. "Against this background, the in vivo anti-inflammatory effects of dietary oleocanthal cannot be as relevant as hypothesized by Beauchamp et al."
Furthermore, oleocanthal was shown to be an activator of the TRPA1 ion channel, which is activated by ibuprofen. Activation of the TRPA1 ion channel by the oleocanthal appears to be responsible for the burning sensation that occurs in the back of the throat when consuming extra-virgin olive oil.
Recently it has been demonstrated that oleocanthal shows potential as a therapeutic weapon for the treatment of inflammatory degenerative joint diseases. Oleocanthal inhibits LPS-induced NO production in J774 macrophages, without affecting cell viability. Moreover, it inhibits MIP-1α and IL-6 mRNA expression, as well as protein synthesis, in both ATDC5 chondrocytes and J774 macrophages. Oleocanthal also inhibits IL-1β, TNF-α and GM-CSF protein synthesis from LPS-stimulated macrophages. Another recent finding has been the ability of oleocanthal to reduce the accumulation of β-amyloid proteins involved in Alzheimer's Disease, via up-regulation of P-glycoprotein and LRP1.

This is an excerpt from the article Oleocanthal from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
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Explaining how extra virgin olive oil…
The mystery of exactly how consumption of extra virgin olive oil helps reduce the risk of Alzheimer's disease (AD) may lie in one component of olive oil that helps ...
phys.org/news/2013-03-extra-virgin-olive-oil-alzheimer.html
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Oleocanthal, Compound In Extra Virgin Olive Oil, Could Protect ...
Mar 31, 2013 ... Here's one more possible benefit of eating a Mediterranean diet.
www.huffingtonpost.com/2013/03/31/olive-oil-alzheimers-disease-extra-virgin-amyloid-beta_n_2935483.html
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Oleocanthal – Why Olive Oil Is Even…
Real answers. Real health. Learn how to support your body's design rather than dictate to it with a prescription pad
designed2win.com/blog/?p=775
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Oleocanthal - Wikipedia, the free encyclopedia
O=CC[C@H](C(=C/C)\C=O)CC(=O)OCCc1ccc(O)cc1. InChI. InChI=1S/ C17H20O5/c1-2-14(12-19)15(7-9-18)11-17(21)22-10-8-13-3-5-16(20)6-4-13/h2- 6,9,12 ...
en.wikipedia.org/wiki/Oleocanthal
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Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a ...
ACS Chem Neurosci. 2013 Feb 25. [Epub ahead of print]. Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective ...
www.ncbi.nlm.nih.gov/pubmed/23414128
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Molecular mechanisms of inflammation. Anti-inflammatory benefits ...
Anti-inflammatory benefits of virgin olive oil and the phenolic compound Oleocanthal. Lucas L, Russell A, Keast R. School of Exercise and Nutrition Sciences, ...
www.ncbi.nlm.nih.gov/pubmed/21443487
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Articles about oleocanthal - Olive Oil Times
Mar 26, 2013 ... Extra virgon olive oil produced from trees in Messini, near Kalamata, were found to contain the largest quantities of the well-known Oleocanthal ...
www.oliveoiltimes.com/tag/oleocanthal
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Oleocanthal | C17H20O5 | ChemSpider
Structure, properties, spectra, suppliers and links for: Oleocanthal, 289030-99-5.
www.chemspider.com/Chemical-Structure.9827154.html
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Can Olive Oil Prevent Alzheimer's? Compound Oleocanthal Blocks ...
Jun 13, 2013 ... An olive oil compound called Oleocanthal may help prevent Alzheimer's due to its ability to clear beta-amyloid plaque from the brain.
www.medicaldaily.com/can-olive-oil-prevent-alzheimers-compound-oleocanthal-blocks-and-degrades-disease-causing-peptide
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Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent ... - InTech
19. Oleocanthal: A Naturally Occurring. Anti-Inflammatory Agent in Virgin Olive Oil. S. Cicerale, L. J. Lucas and R. S. J. Keast. School of Exercise and Nutrition ...
www.intechopen.com/download/pdf/27042
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Oleocanthal in science
Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a ...
Feb 25, 2013... University of Louisiana at Monroe , 1800 Bienville Drive, Monroe, ... Oleocanthal, a phenolic component of extra-virgin olive oil, has been ...
Oleocanthal.com - Monell Chemical Senses Center
The sensory similarities between Oleocanthal and ibuprofen led scientists at Monell and the University of the Sciences to investigate potential common ...
Can Olive Oil Prevent Alzheimer's? Compound Oleocanthal Blocks ...
Jun 13, 2013 ... Researchers from the University of Louisiana at Monroe applied different concentrations of Oleocanthal to mice brain cell cultures, and, for the ...
Explaining how extra virgin olive oil protects against Alzheimer's ...
Mar 20, 2013 ... Kaddoumi's team sought evidence on whether Oleocanthal helps .... (Medical Xpress)—Deakin University researchers are investigating the ...
Oleocanthal, Compound In Extra Virgin Olive Oil, Could Protect ...
Mar 31, 2013 ... Researchers from the University of Louisiana are a step closer to ... a dose of extracted Oleocanthal from extra virgin olive oil twice daily.
Oleocanthal - Chemistry, Structures & 3D Molecules @ 3Dchem.com
The sensory similarities between Oleocanthal and ibuprofen led scientists at Monell and the University of the Sciences to investigate potential common ...
[PDF]Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent ... - InTech
Sensory Science Group, Deakin University, Melbourne,. Australia ... ligstroside aglycone (more commonly known as Oleocanthal) has supported speculation that .
Natural Compound In Extra-virgin Olive Oil -- Oleocanthal -- May ...
Sep 29, 2009 ... Also contributing to the work were chemist Amos B. Smith, III, of Monell and the University of Pennsylvania, who supplied the Oleocanthal; ...
Olive-Oil-Derived Oleocanthal -May Help Prevent Alzheimer's-Anti ...
May 31, 2013 ... Also contributing to the work were chemist Amos B. Smith, III, of Monell and the University of Pennsylvania, who supplied the Oleocanthal; ...
Oleocanthal May Help Prevent, Treat Alzheimer's
Sep 30, 2009 ... Also contributing to the work were chemist Amos B. Smith, III, of Monell and the University of Pennsylvania, who supplied the Oleocanthal; ...
Books on the term Oleocanthal
Food as a Medicine: Healthful Oleocanthal in Australian Olive Oil
Food as a Medicine: Healthful Oleocanthal in Australian Olive Oil
Sara Cicerale, 2009
Oleocanthal has gained much interest as a natural anti-inflammatory phenolic component in olive oil.
Certified Organic Extra Virgin Olive Oil 1,000 mg 120 Sgels
Certified Organic Extra Virgin Olive Oil 1,000 mg 120 Sgels
Support cardiovascular health with Swanson Extra Virgin Olive Oil! Olive oil is one of the pillars supporting the healthful reputation of the world-renowned "Mediterranean Diet." The olive's naturally impressive fatty acid profile and unique polyphenols could explain why studies link cardiovascular health with those who consume olive...
Chemistry and Pharmacology of Anticancer Drugs
Chemistry and Pharmacology of Anticancer Drugs
David E. Thurston, 2006
9.4.7.2 Oleocanthal It was reported in Nature in 2005 that Oleocanthal, the dialdehydic form of (-)deacetoxy-ligstroside aglycone ("oleo" for olive, "canth" for sting, and "al" for aldehyde), is present in newly pressed extra-virgin olive oil (see  ...
Seagate Olive Oil Extra Virgin 1000 mg, 100 softgels
Seagate Olive Oil Extra Virgin 1000 mg, 100 softgels
Seagate Olive Oil (extra virgin) 1000 mg (100 softgels) is an easy way to increase the consumption of monounsaturated fatty acids, primarily Oleic Acid, without the need to taste the oil or add it to a meal. Seagate's Olive Oil is an important part of a diet supporting the reduction in the risk of coronary heart disease and the reduction of LD...
Phytochemicals, Signal Transduction, and Neurological Disorders
Phytochemicals, Signal Transduction, and Neurological Disorders
Akhlaq A. Farooqui, 2012
Olive oil component, Oleocanthal, the dialdehydic form of (-)-deacetoxy- ligstroside aglycone, inhibits tau fibrillization by interacting with the T40 and MT- binding region K18 of tau protein (Li et al. 2009). Using PHF6 consisting of the amino acid ...
Oleocanthal Olive Oil Molecule Canvas Print / Canvas Art - Artist Dr Tim Evans
Oleocanthal Olive Oil Molecule Canvas Print / Canvas Art - Artist Dr Tim Evans
This is a beautiful stretched-canvas print wrapped on 1.5" thick stretcher bars. The print is professionally printed, assembled, and shipped within 2 - 3 business days from our production facility in North Carolina and arrives ready-to-hang on your wall. Fine Art America is home to more than 75,000 artists from all over the world who entrust u...
The Mediterranean Diet: Health and Science
The Mediterranean Diet: Health and Science
Richard Hoffman, Mariette Gerber, 2013
Some EVOOs have a distinct peppery bite at the back ofthe throat and this effect is due to Oleocanthal. A similar ... This similarity between Oleocanthal and ibuprofen provoked an examination of the anti-inflammatory actions of Oleocanthal.
The Real Secret to Optimal Health
The Real Secret to Optimal Health
Anthony Galea, 2013
Researchers reporting in the September 1, 2005 issue of the journal Nature have shown that fresh extra virgin olive oil contains a natural compound, Oleocanthal, which is a non-steroidal anti-inflammatory agent that has the same pain ...
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Blog posts on the term
Oleocanthal
Can Olive Oil Prevent Alzheimer's? Compound Oleocanthal Blocks And Degrades Disease-Causing Peptide
An olive oil compound called Oleocanthal may help prevent Alzheimer's due to its ability to clear beta-amyloid plaque from the brain.
www.medicaldaily.com/can-olive-oil-prevent-alzheimers-compound-oleocanthal-blocks-and-degrades-disease-causing-peptide
Explaining how extra virgin olive oil protects against Alzheimer's disease
The mystery of exactly how consumption of extra virgin olive oil helps reduce the risk of Alzheimer's disease (AD) may lie in one component of olive oil that helps shuttle the abnormal AD proteins out of the brain, scientists are reporting in a new study. It appears in the journal ACS Chemical Neuroscience.
phys.org/news/2013-03-extra-virgin-olive-oil-alzheimer.html
Olive-Oil-Derived Oleocanthal -May Help Prevent Alzheimer’s-Anti Inflam-ACS Chem Neurosci 2013 | Adjust2it's Blog
Posted by: Kevin G. Parker, D.C. Olive-Oil-Derived Oleocanthal -May Help Prevent Alzheimer’s-Anti Inflammatory Key points from the 4 studies below 1. Previously researchers thought EVOO benefits were from MUFA's. (Monounsaturated Fatty acids) 2. Now scientists discovered Oleocanthal in EVOO may be the key. 3. Oleocanthal is naturally occuring in EVOO and has a peppery stinging…
adjust2it.wordpress.com/2013/05/31/olive-oil-derived-oleocanthal-may-help-prevent-alzheimers-anti-inflam-acs-chem-neurosci-2013/
Oleocanthal – Why Olive Oil Is Even Better Than You Knew | Designed2Win®
Posted on April 2, 2013 by H. L.
designed2win.com/blog/?p=775
Compound in olive oil possibly linked to Alzheimer’s prevention | Micro.Science.Life
It is as though a common knowledge when it comes to Mediterranean diet that it welcomes quite a substantial amount of benefits to our health. Most of us have always presumed that as due to the high content of monosaturated fats in olive oil - extra virgin olive oil (EVOO) in particular, which is one…
microsciencelife.wordpress.com/2013/06/17/123/
How Extra Virgin Olive Oil Can Protect from Alzheimer’s
Researchers say Oleocanthal found in extra-virgin olive oil has the potential to reduce the risk of Alzheimer’s Disease.
www.oliveoiltimes.com/olive-oil-health-news/how-extra-virgin-olive-oil-can-protect-from-alzheimers/33529
Herbal Remedies and Complementary Therapies in the News: Oleocanthal Could Protect Against Alzheimer's Disease
Here’s one more possible benefit of eating a Mediterranean diet. Researchers from the University of Louisiana are a step closer to understanding why Alzheimer's disease seems to be not as common in Mediterranean countries, and the possible role olive oil may play in protecting against the memory-robbing disease.
www.complementarytherapynews.co.uk/2013/04/oleocanthal-could-protect-against.html
The Smart Set: The Oily Truth - February 12, 2008
The connection between ibuprofen and olive oil may finally end the healthy diet debate.
thesmartset.com/article/article02120801.aspx
Meditations on Medicine: Oleocanthal: The Next Big Thing?
Chances are, you’ve never heard of this. That is, unless you read Thomas Mueller’s 2011 exposé on olive oil, Extra Virginity.
drpaddock.blogspot.com/2012/07/oleocanthal-next-big-thing.html
Servicio de noticias en salud Al Día » El oleocanthal podría ser útil en mieloma múltiple
boletinaldia.sld.cu/aldia/2013/04/26/el-oleocanthal-podria-ser-util-en-mieloma-multiple/
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