Glutamate-gated chloride channel
Chloride channels are a superfamily of poorly understood ion channels consisting of approximately 13 members.
Chloride channels display a variety of important physiological and cellular roles that include regulation of pH, volume homeostasis, organic solute transport, cell migration, cell proliferation and differentiation. Based on sequence homology the chloride channels can be subdivided into a number of groups. The importance of one such group, the CLC family of chloride channels, can be seen from the diseases that develop when the channel does not function normally.
This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three CLC subfamilies are found in animals. CLC-1 (P35523) is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney [3]. These proteins contain two CBS domains. Chloride channels are also important for maintaining safe ion concentrations within plant cells.

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MECHANISM OF ACTION. Glutamate-gated chloride channel Ivermectin binds with high affinity to Glutamate-gated chloride channels which occur in invertebrate nerve and ...
www.stanford.edu/class/humbio103/ParaSites2005/Ivermectin/mechanism%20of%20action.htm
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Glutamate-gated chloride channels.
Oct 4, 2012 ... Glutamate-gated chloride channels (GluCls) are found only in protostome invertebrate phyla but are closely related to mammalian glycine ...
www.ncbi.nlm.nih.gov/pubmed/23038250
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Chloride channel - Wikipedia, the free encyclopedia
Selamectin works by replacing glutamate which normally interacts with receptors that open chloride channels at muscle synapses found in parasites.
en.wikipedia.org/wiki/Chloride_channel
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Glutamate-gated chloride channels and the mode of ... - ResearchGate
clear that they exert their anthelmintic effects by binding to Glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells.
www.researchgate.net/publication/7210618_Glutamate-gated_chloride_channels_and_the_mode_of_action_of_the_avermectinmilbemycin_anthelmintics/file/5046351787c0f317da.pdf
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An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the ...
Nematode Glutamate-gated chloride channels are targets of the macrocyclic lactones, the most important group of anthelmintics available. In Xenopus laevis ...
molpharm.aspetjournals.org/content/75/6/1347.full.pdf
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Glutamate-gated chloride channel subunit beta precursor ... - UniProt
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www.uniprot.org/uniprot/Q17328
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An ivermectin-sensitive glutamate-gated chloride channel subunit ...
Dirofilaria immitis is a filarial nematode that infects dogs and causes cardiopulmonary disease. The most effective way of controlling the infection is by chemo.
www.sciencedirect.com/science/article/pii/S0020751904000979
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Genetic variability of glutamate-gated chloride channel genes in ...
The Glutamate-gated chloride channels (GluCls) are members of the ligand- gated ion channel superfamily that are thought to be involved in the mode of action ...
journals.cambridge.org/article_S0031182004006183
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Glutamate-Gated Chloride Channels of Haemonchus contortus ...
Jul 26, 2011 ... We tested this using the Glutamate-gated chloride channel (GluCl) gene family, which forms the ivermectin drug target and are candidate ...
www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0022390
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Drug-resistant Drosophila indicate glutamate-gated chloride ...
Drug-resistant Drosophila indicate Glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin. Nanci S. Kane*†, Birgit ...
www.pnas.org/content/97/25/13949.full.pdf
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Glutamate-gated chloride channel in science
An Ivermectin-Sensitive Glutamate-Gated Chloride Channel from the ...
Department of Biology and Biochemistry, University of Bath, Claverton Down, ... Nematode Glutamate-gated chloride channels are targets of the macrocyclic ...
Glutamate-gated chloride channels.
Oct 4, 2012 ... Glutamate-gated chloride channels. Wolstenholme AJ. Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA.
Glutamate-Gated Chloride Channels of Haemonchus contortus ...
Jul 26, 2011 ... Affiliation: Departmenty of Biology and Biochemistry, University of Bath, ... We tested this using the Glutamate-gated chloride channel (GluCl) ...
[PDF]Glutamate-gated chloride channels and the mode of ... - ResearchGate
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK. .... oocytes revealed a Glutamate-gated chloride channel.
Distribution of glutamate‐gated chloride channel subunits in the ...
May 30, 2003 ... Distribution of Glutamate-gated chloride channel subunits in the parasitic nematode Haemonchus contortus. Virginia Portillo,; Suchitra ...
An ivermectin-sensitive glutamate-gated chloride channel subunit ...
... Departments · Business · About · University of Bath homepage ... An ivermectin -sensitive Glutamate-gated chloride channel subunit from Dirofilaria immitis ...
[PDF]Genetic variability of glutamate-gated chloride channel genes in ...
Institute of Parasitology, McGill University, 21 111 Lakeshore Road, ... The Glutamate-gated chloride channels (GluCls) are members of the ligand-gated ion ...
GLC-3: A fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L ...
1, Department of Biology & Biochemistry, University of Bath, Bath BA2 7AY, UK ... Glutamate-gated chloride channels (GluCl) are a class of ligand-gated ion ...
Ion Channel Diseases - Neuromuscular Disease Center
Extracellular ligand-gated Cl- channels (ELG) ..... Spontaneous synaptic release of glutamate in superficial spinal laminae I-II; Excitatory neurotransmission.
Books on the term Glutamate-gated chloride channel
Molecular Biochemistry and Physiology of Helminth Neuromuscular ...
Molecular Biochemistry and Physiology of Helminth Neuromuscular ...
D. W. Halton, 1997
S191 Molecular biology and electrophysiology of glutamate- gated chloride channels of invertebrates D. F. CULLY*f, H. WILKINSON, D. K. VASSILATIS, A. ETTER and J. P. ARENA f Department of Genetics and Molecular Biology and ...
Insect Nicotinic Acetylcholine Receptors
Insect Nicotinic Acetylcholine Receptors
Steeve Herve Thany, 2011
evidence for: Glutamate-gated chloride channels in insect muscle and in mollusk and crustacean neurons,54-57 excitatory GABA currents in crustacean, mollusk and nematode muscle,58-61 inhibitory histamine currents in the insect visual ...
Insect Pharmacology: Channels, Receptors, Toxins and Enzymes
Insect Pharmacology: Channels, Receptors, Toxins and Enzymes
Lawrence I. Gilbert, Sarjeet S. Gill, 2010
Studies on cloned, expressed Glutamate-gated chloride channels from nematodes and insects provide strong ... (1994) cloned two complementary DNAs encoding avermectin-sensitive Glutamate-gated chloride channel subunits from the ...
Pharmacology of Ionic Channel Function: Activators and Inhibitors ...
Pharmacology of Ionic Channel Function: Activators and Inhibitors ...
Makoto Endō, Yoshihisa Kurachi, Masayoshi Mishina, 2000
Nature 358:727-733 Cully DF, Vassilatis DK, Liu KK, Paress PS, Van der Ploeg LH, Schaeffer JM, Arena JP (1994) Cloning of an avermectin-sensitive Glutamate-gated chloride channel from Caenorhabditis elegans. Nature 371:707-711 Cully  ...
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Blog posts on the term
Glutamate-gated chloride channel
An Engineered Glutamate-gated Chloride (GluCl) Channel for Sensitive, Consistent Neuronal Silencing by Ivermectin
www.jbc.org/content/288/29/21029.abstract
Cys-Loop Ligand-Gated Chloride Channels in Dorsal Unpaired Median Neurons of Locusta migratoria
jn.physiology.org/content/103/5/2587.abstract
Binding characteristics of emamectin benzoate to the putative glutamate-gated chloride channels of Lepeophtheirus salmonis | Biological Sciences Paper
www.bthesis.com/15125.html
maceemunyjribuqueta - mg 132 Resistance to macrocyclic lactones ...
my.opera.com/maceemunyjribuqueta/blog/2013/08/10/mg-132-resistance-to-macrocyclic-lactones-in-the-strongylid
Parasites & Vectors | Full text | Eliminating female Anopheles arabiensis by spiking blood meals with toxicants as a sex separation method in the context of the sterile insect technique
Ivermectin has longevity reducing effects in several insect species, including disease transmitting mosquitoes after feeding on hosts that have received ivermectin treatment. This has important implications in mosquito population control and thus the reduction of disease transmission. In addition, ivermectin could play an enormous role in mosquito control operations by its use in the female elimination process during mass-rearing, enabling the release of only sterile males in the context of the sterile insect technique (SIT).
www.parasitesandvectors.com/content/6/1/197
The Cellular Scale: GABA, how exciting!
I would like to thank my good friend Anonymous for asking me a great question on a previous post. Anonymous asks: "Are there any known transmitters in the NS that activate both inhibitory receptor subtypes AND excitatory receptor subtypes? Or does every known transmitter activate EITHER a bunch of excitatory subtypes OR a bunch of inhibitory subtypes?"  (btw.
cellularscale.blogspot.com/2013/02/gaba-how-exciting.html
Ivermectin, What isIvermectin? About its Science, Chemistry and Structure
Find out about the science and chemistry of Ivermectin (Avermectin, Stromectol, Mectizan), see colourful images of Ivermectin and explore interactive 3D molecules of Ivermectin
www.3dchem.com/molecules.asp?ID=321
Fipronil is … | What is this ?
Fipronil Fipronil is a broad spectrum insecticide that disrupts the insect central nervous system by blocking the passage of chloride ions through the GABA
topdefinitions.com/2013/07/18/fipronil-is/
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