Allosteric protein
In biochemistry, allosteric regulation is the regulation of an enzyme or other protein by binding an effector molecule at the protein's allosteric site (that is, a site other than the protein's active site). Effectors that enhance the protein's activity are referred to as allosteric activators, whereas those that decrease the protein's activity are called allosteric inhibitors. The term allostery comes from the Greek allos (ἄλλος), "other", and stereos (στερεὀς), "solid (object)", in reference to the fact that the regulatory site of an allosteric protein is physically distinct from its active site. Allosteric regulations are a natural example of control loops, such as feedback from downstream products or feedforward from upstream substrates. Long-range allostery is especially important in cell signaling.

This is an excerpt from the article Allosteric protein from the Wikipedia free encyclopedia. A list of authors is available at Wikipedia.
The article Allosteric protein at en.wikipedia.org was accessed 96 times in the last 30 days. (as of: 07/26/2013)
Images on Allosteric protein
Preview image:
Original:
Search results from Google and Bing
1
1
1
Allosteric regulation - Wikipedia, the free encyclopedia
In biochemistry, allosteric regulation is the regulation of an enzyme or other protein by binding an effector molecule at the protein's allosteric site (that is, a site ...
en.wikipedia.org/wiki/Allosteric_regulation
2
>30
2
allosteric protein definition
Jul 26, 2004 ... A protein whose shape is changed when it binds a particular molecule. In the new shape the protein's ability to react to a second molecule is ...
groups.molbiosci.northwestern.edu/holmgren/Glossary/Definitions/Def-A/allosteric_protein.html
3
>30
3
Allosteric Protein - definition from Biology-Online.org
Definition and other additional information on Allosteric protein from Biology- Online.org dictionary.
www.biology-online.org/dictionary/Allosteric_Protein
4
>30
4
Allosteric regulation
In biochemistry, allosteric regulation is the regulation of an enzyme or other protein by binding an effector molecule at the protein's allosteric site (that is, a site ...
www.princeton.edu/~achaney/tmve/wiki100k/docs/Allosteric_regulation.html
5
>30
5
What is allosteric regulation? - Yahoo! Answers
In biochemistry, 'allosteric regulation' is the regulation of an enzyme or protein by binding an effector molecule at the protein's allosteric site ...
answers.yahoo.com/question/index?qid=20101212112713AATxRxP
6
>30
6
Systematic identification of allosteric protein-metabolite ... - Nature
Mar 3, 2013 ... Integrating metabolomics and computational modeling provides a method to identify allosteric enzyme-metabolite interactions, which have ...
www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.2489.html
7
>30
7
ASD: a comprehensive database of allosteric proteins and modulators
Zhimin Huang,1 Liang Zhu,2 Yan Cao,3 Geng Wu,2 Xinyi Liu,1,4 Yingyi Chen,1,4 Qi Wang,2 Ting Shi,1,4 Yaxue Zhao,1 Yuefei Wang,1 Weihua Li,5 Yixue Li,6 ...
www.ncbi.nlm.nih.gov/pmc/articles/PMC3013650/
8
>30
8
Systematic identification of allosteric protein-metabolite interactions ...
Nat Biotechnol. 2013 Apr;31(4):357-61. doi: 10.1038/nbt.2489. Epub 2013 Mar 3. Systematic identification of Allosteric protein-metabolite interactions that control ...
www.ncbi.nlm.nih.gov/pubmed/23455438
9
>30
9
Kinetic response of a photoperturbed allosteric protein
Jul 1, 2013 ... Abstract. By covalently linking an azobenzene photoswitch across the binding groove of a PDZ domain, a conformational transition, similar to ...
www.pnas.org/content/early/2013/06/26/1306323110.short
10
>30
10
Computation of Conformational Coupling in Allosteric Proteins
Abstract. In allosteric regulation, an effector molecule binding a protein at one site induces conformational changes, which alter structure and function at a distant ...
www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000484
Search results for "Allosteric protein"
Google: approx. 2.230.000
Allosteric protein in science
ASD: a comprehensive database of allosteric proteins and modulators
Published by Oxford University Press. ASD: a comprehensive database of Allosteric proteins and modulators. Zhimin Huang,1 Liang Zhu,2 Yan Cao,3 Geng Wu ...
Kinetic response of a photoperturbed allosteric protein
Jul 1, 2013 ... Kinetic response of a photoperturbed Allosteric protein ... Stanford University's HighWire Press® | Online ISSN 1091-6490. Copyright © 2013 ...
Computation of Conformational Coupling in Allosteric Proteins
Computation of Conformational Coupling in Allosteric proteins. Brian A. Kidd,. Affiliation: Department of Bioengineering, University of Washington, Seattle, ...
Allosteric Protein Modulation: What is it and Why is it Important?
Mar 23, 2011 ... Functional proteins (receptors, enzymes, ion channels) sense their ... Ph.D., is Professor in the Department of Pharmacology, University of ...
Surface Sites for Engineering Allosteric Control in Proteins - Science
Oct 17, 2008 ... Such linkages suggest a concept for engineering allosteric control into proteins: The intramolecular networks of two proteins could be joined ...
Jeanne Hardy-Faculty-Department of Chemistry-University of ...
BS/MS 1994, Utah State University, PhD 2000, University of California at Berkeley, ... Designed Allosteric proteins are of great utility because of their exquisite ...
KALODIMOS GROUP HOME PAGE
The ability to inhibit binding or enzymatic activity is key to preventing aberrant behaviors of proteins. Allosteric inhibition is desirable as it offers several ...
Cell - Hot Spots for Allosteric Regulation on Protein Surfaces
Hot Spots for Allosteric Regulation on Protein Surfaces. Cell, Volume 147, Issue 7, Pages 1564-1575, Publication Date 23 December 2011. Copyright © 2011 ...
Spanning binding sites on allosteric proteins with polymer-linked ...
Spanning binding sites on Allosteric proteins with polymer-linked ligand dimers ... Department of Molecular and Cellular Pharmacology, University of Miami ...
[PDF]belief propagation reveals allosteric mechanisms in proteins 1.
Computer Science Department, Carnegie Mellon University,. Pittsburgh, PA 15213 ... The physical mechanisms involved in allosteric regulation remain unclear.
Books on the term Allosteric protein
Oligomerization and Allosteric Modulation in G-Protein Coupled ...
Oligomerization and Allosteric Modulation in G-Protein Coupled ...
2012
In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors.
Protein Structure and Function
Protein Structure and Function
Gregory A. Petsko, Dagmar Ringe, 2004
Because structural changes are produced in both models, this form of regulation is called allostery from the Greek for “another structure”, and a protein that is regulated in this way is called an Allosteric protein. A molecule that stabilizes the  ...
Artificial Allosteric Control of Proteins Through Mechanical Tension
Artificial Allosteric Control of Proteins Through Mechanical Tension
Brian David Choi, 2006
The profound relationship between a proteins conformational change and function is one that lies at the heart of understanding, and possibly controlling biological macromolecules.
Molecular Biology of the Cell
Molecular Biology of the Cell
Bruce Alberts, 1989
Alternatively, phosphorylation could create a charge attraction that brings together two separated parts of an Allosteric protein. Figure 3-62 An allosteric " walking" protein. Although its three different conformations allow it to wander randomly ...
Development of Google searches


Blog posts on the term
Allosteric protein
Allosteric Coupling in the Bacterial Adhesive Protein FimH
www.jbc.org/content/288/33/24128.short
On the G-Protein-Coupled Receptor Heteromers and Their Allosteric Receptor-Receptor Interactions in the Central Nervous System: Focus on Their Role in Pain Modulation
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international, peer-reviewed journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
www.hindawi.com/journals/ecam/2013/563716/
The endozepine mystery | Beyond the Ion Channel
Compound unknown. GABA is the main inhibitory neurotransmitter in the Central Nervous System and its effect is mediated through GABA receptors. Benzodiazepines are compounds that reinforce the action of GABA in the brain, which gives them antiepileptic properties. Consequently, benzodiazepines are one of the most common groups of antiepileptic drugs used to interrupt acute epileptic…
channelopathist.net/2013/08/28/the-endozepine-mystery/
Introduction of Artificial Allosteric Sites on Functional Proteins to Externally Control Function and Binding-University of California System: University of California, Los Angeles - UCLA
Brief description unavailable
www.ibridgenetwork.org/ucla/introduction-of-artificial-allosteric-sites-on-functional-pro
Taming shape-shifters: analyzing dynamic protein structures on-chip « Lab on a Chip Blog
Researchers at York University in Toronto have developed an integrated microfluidic device to facilitate analysis of modified protein structures after biochemical reactions. The platform guides a protein right through from a controlled reaction, functional labeling, and fragmentation zones to a coupled mass spectrometer for determination of the protein’s secondary structure.
blogs.rsc.org/lc/2013/06/21/taming-shape-shifters-analyzing-dynamic-protein-structures-on-chip/
Assessing the structural conservation of protein pockets to study functional and allosteric sites: implications for drug discovery - Dipòsit Digital de Documents de la UAB
Background: With the classical, active-site oriented drug-development approach reaching its limits, protein ligand-binding sites in general and allosteric sites in particular are increasingly attracting the interest of medicinal chemists in the search for new types of targets and strategies to drug development. Given that allostery represents one of the most common and powerful means to regulate protein function, the traditional drug discovery approach of targeting active sites can be extended by targeting allosteric or regulatory protein pockets that may allow the discovery of not only novel drug-like inhibitors, but activators as well. The wealth of available protein structural data can be exploited to further increase our understanding of allosterism, which in turn may have therapeutic applications. A first step in this direction is to identify and characterize putative effector sites that may be present in already available structural data. Results: We performed a large-scale study of protein cavities as potential allosteric and functional sites, by integrating publicly available information on protein sequences, structures and active sites for more than a thousand protein families. By identifying common pockets across different structures of the same protein family we developed a method to measure the pocket's structural conservation. The method was first parameterized using known active sites. We characterized the predicted pockets in terms of sequence and structural conservation, backbone flexibility and electrostatic potential. Although these different measures do not tend to correlate, their combination is useful in selecting functional and regulatory sites, as a detailed analysis of a handful of protein families shows. We finally estimated the numbers of potential allosteric or regulatory pockets that may be present in the data set, finding that pockets with putative functional and effector characteristics are widespread across protein families. Conclusions: Our results show that structurally conserved pockets are a common feature of protein families. The structural conservation of protein pockets, combined with other characteristics, can be exploited in drug discovery procedures, in particular for the selection of the most appropriate target protein and pocket for the design of drugs against entire protein families or subfamilies (e.g. for the development of broad-spectrum antimicrobials) or against a specific protein (e.g. in attempting to reduce side effects). Panjkovich, Alejandro; Daura Ribera, Xavier
ddd.uab.es/record/106813?ln=ca
- Mapping allosteric interactions
blogs.ethz.ch/imsbnews/2013/03/11/mapping-allosteric-interactions/
Genome Biology | Full text | Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkages
Allosteric communications are vital for cellular signaling. Here we explore a relationship between protein architectural organization and shortcuts in signaling pathways.
genomebiology.com/2007/8/5/r92
Biochemistry: Proteins: Myoglobin and Hemoglobin (MCQS) | NEET TIMES
www.neettimes.com/biochemistry-proteins-myoglobin-and-hemoglobin/
Multiple Choice Questions on Protein Function ~ Biology Exams 4 U
A biology exam preparation portal
www.biologyexams4u.com/2013/08/multiple-choice-questions-on-protein.html
123